Nucleolin: a binding partner of G-quadruplex structures

Trends Cell Biol. 2022 Jul;32(7):561-564. doi: 10.1016/j.tcb.2022.03.003. Epub 2022 Apr 8.

Abstract

Nucleolin protein is involved in a plethora of cellular pathways across the nucleolus, nucleus, and cytoplasm. The association of its RNA-binding domain (RBD) and its RGG (arginine-glycine-glycine-rich) domain allows it to interact with G-quadruplex structures in nucleic acids. We highlight evidence that the nucleolin/G-quadruplex partnership is of extensive relevance to neurodegenerative disease, cancer, and viral infections.

Keywords: G-quadruplex; interaction; ligands; nucleolin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • G-Quadruplexes*
  • Humans
  • Neoplasms
  • Neurodegenerative Diseases
  • Nucleolin
  • Phosphoproteins* / metabolism
  • Protein Binding
  • RNA-Binding Proteins* / metabolism
  • Virus Diseases

Substances

  • Phosphoproteins
  • RNA-Binding Proteins