This review summarises the current knowledge of the use of collaborative care (CC) in Denmark. CC is an evidence-based approach to the treatment of depression and anxiety in primary care services. An optimised treatment is needed in Denmark, and a Danish CC model called Collabri, later Collabri Flex, was developed and evaluated in randomised controlled trials. The evaluation in the randomised controlled trials was needed since CC is an organizational model primarily tested in countries outside of Scandinavia. The effect evaluated is promising, but the cost-effectiveness of the model still needs to be established (ongoing study).