Implication of Platelets in Immuno-Thrombosis and Thrombo-Inflammation

Younes Zaid; Yahye Merhi

doi:10.3389/fcvm.2022.863846

Implication of Platelets in Immuno-Thrombosis and Thrombo-Inflammation

Front Cardiovasc Med. 2022 Mar 25:9:863846. doi: 10.3389/fcvm.2022.863846. eCollection 2022.

Authors

Younes Zaid^{1

2}, Yahye Merhi³

Affiliations

¹ Laboratory of Materials, Nanotechnology and Environment, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco.
² Immunology and Biodiversity Laboratory, Department of Biology, Faculty of Sciences, Hassan II University, Casablanca, Morocco.
³ Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Research Center, The Université de Montréal, Montreal, QC, Canada.

Abstract

In addition to their well-described hemostatic function, platelets are active participants in innate and adaptive immunity. Inflammation and immunity are closely related to changes in platelet reactions and enhanced platelet function in thrombo-inflammation, as well as in microbial and virus infections. A platelet's immune function is incompletely understood, but an important balance exists between its protective and pathogenic responses and its thrombotic and inflammatory functions. As the mediator of vascular homeostasis, platelets interact with neutrophils, bacteria and virus by expressing specific receptors and releasing granules, transferring RNA, and secreting mitochondria, which controls hemostasis and thrombosis, infection, and innate and adaptive immunity. This review focuses on the involvement of platelets during immuno-thrombosis and thrombo-inflammation.

Keywords: NETosis; extracellular vesicles (EVs); immuno-thrombosis; platelets; thrombo-inflammation.

Publication types

Review