Multifunctional Nanomaterials for Ferroptotic Cancer Therapy

Zhiyuan Shi; Jianzhong Zheng; Wenbin Tang; Yang Bai; Lei Zhang; Zuodong Xuan; Huimin Sun; Chen Shao

doi:10.3389/fchem.2022.868630

Multifunctional Nanomaterials for Ferroptotic Cancer Therapy

Front Chem. 2022 Mar 24:10:868630. doi: 10.3389/fchem.2022.868630. eCollection 2022.

Authors

Zhiyuan Shi¹, Jianzhong Zheng¹, Wenbin Tang¹, Yang Bai¹, Lei Zhang², Zuodong Xuan¹, Huimin Sun³, Chen Shao¹

Affiliations

¹ Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
² School of Public Health, Xiamen Univerisity, Xiamen, China.
³ Central Laboratory, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

Abstract

Patient outcomes from the current clinical cancer therapy remain still far from satisfactory. However, in recent years, several biomedical discoveries and nanotechnological innovations have been made, so there is an impetus to combine these with conventional treatments to improve patient experience and disease prognosis. Ferroptosis, a term first coined in 2012, is an iron-dependent regulated cell death (RCD) based on the production of reactive oxygen species (ROS) and the consequent oxidization of polyunsaturated fatty acids (PUFAs). Many nanomaterials that can induce ferroptosis have been explored for applications in cancer therapy. In this review, we summarize the recent developments in ferroptosis-based nanomaterials for cancer therapy and discuss the future of ferroptosis, nanomedicine, and cancer therapy.

Keywords: cancer therapy; ferroptosis; ferroptosis inducers; nanomaterial; reactive oxygen species.

Publication types

Review