Thyroid Function Assessment in Saudi Males with Metabolic Syndrome

Fahad Khalid Aldhafiri; Fathy Elsayed Abdelgawad; Gihan Mohamed Mohamed Bakri; Tamer Saber

doi:10.4103/jpbs.jpbs_745_21

Thyroid Function Assessment in Saudi Males with Metabolic Syndrome

J Pharm Bioallied Sci. 2021 Oct-Dec;13(4):352-359. doi: 10.4103/jpbs.jpbs_745_21. Epub 2022 Mar 4.

Authors

Fahad Khalid Aldhafiri¹, Fathy Elsayed Abdelgawad^{2

3}, Gihan Mohamed Mohamed Bakri⁴, Tamer Saber⁵

Affiliations

¹ Department of Public Health, College of Applied Medical Sciences, Majmaah University, Al Majmaah, Saudi Arabia.
² Medical Biochemistry Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
³ Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, KSA.
⁴ University Medical Center, Islamic University of Madinah, Madinah, KSA.
⁵ Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Abstract

Background: Metabolic Syndrome (MetS) is a multifactor condition associated with cardiovascular risk. Thyroid hormones regulate MetS components via controlling energy homeostasis, lipids, and glucose metabolism. The risk ratio for MetS and related disorders changes between males and females. Aim and Objectives: Study aim to access thyroid functions in Saudi population with metabolic syndrome.

Materials and methods: The current study sought to evaluate the impact of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) in predicting the risk of MetS. A total of 200 (MetS 100 and control 100) Saudi Arabian males were enrolled for the study, and after applying eligibility criteria, the eligible study size was examined for the physical test (chest, abdominal, and general examination with stress on blood pressure measurement) and anthropometric parameters (bodyweight, body mass index, and waist circumference).

Results: In the present study, the biochemical parameters, such as TSH, FT3, FT4, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), high-density lipoprotein (LDL), fasting glucose, and fasting insulin were measured in the study group, and statistical analysis was also performed. The results revealed that the MetS and control differ in terms of physical, anthropometric, and biochemical markers. The study showed that thyroid dysfunction (TD) and MetS are closely associated with the difference in physical, anthropometric, and metabolic characteristics.

Conclusion: The result demonstrated hypothyroidism major risk factor due to TD in MetS. These findings provide a scientific basis for diagnosis and the management of TD, associated MetS, and cardiovascular disease (CVD).