Outcomes of Sarcopenia Treatment for Malignant Bone and Soft Tissue Tumors in Elderly Patients

Yoshitaka Ban; Hoshi Manabu; Naoto Oebisu; Akiyoshi Shimatani; Naoki Takada; Hiroaki Nakamura

doi:10.21873/cdp.10094

Outcomes of Sarcopenia Treatment for Malignant Bone and Soft Tissue Tumors in Elderly Patients

Cancer Diagn Progn. 2022 Mar 3;2(2):194-200. doi: 10.21873/cdp.10094. eCollection 2022 Mar-Apr.

Authors

Yoshitaka Ban¹, Hoshi Manabu¹, Naoto Oebisu¹, Akiyoshi Shimatani¹, Naoki Takada¹, Hiroaki Nakamura¹

Affiliation

¹ Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Abstract

Background/aim: We determined the impact of sarcopenia on the treatment outcomes of malignant bone and soft tissue tumors in elderly patients.

Patients and methods: We retrospectively reviewed 76 patients (age ≥65 years) who were treated for malignant bone and soft tissue tumors. Sarcopenia was assessed by measuring the cross-sectional area of the psoas muscles at the L3 vertebra from preoperative computed tomography images and categorized using the total psoas area/m ² (TPA/m ² ) ≤5.0 cm ² /m ² . The patients' clinical data were then evaluated.

Results: The operation time, length of hospital stay, and median overall survival were not different between the sarcopenia (n=41) and no-sarcopenia (n=35) groups. The local recurrence rate (p=0.01) and incidence of postoperative complications (p=0.02) significantly differed between both groups. The TPA/m ² of both groups significantly decreased at the final follow-up.

Conclusion: Sarcopenia negatively influenced wound healing and local recurrence, and was significantly exacerbated postoperatively in all elderly patients.

Keywords: Sarcopenia; local recurrence; malignant bone; postoperative complications; soft tissue tumor; wide resection.