Survival, functional, and quality of life outcomes between total glossectomy with and without total laryngectomy: A narrative review

Abstract

Background: A total glossectomy (TG) may be required for advanced tongue tumors. TG with total laryngectomy (TGL) may be indicated in some cases with tumor extension into the larynx or high risk of aspiration. Total glossectomy with laryngeal preservation (TGLP) may preserve phonation ability relative to TGL, yet TGLP may increase the risk of aspiration.

Methods: For this narrative review, we performed a comprehensive literature search of studies relevant to TG and TGL. Clinical studies investigating survival, functional outcomes, and quality of life in following TGLP or TGL were of particular interest.

Results: Few studies in the literature directly compare survival, functional, and quality of life (QOL) outcomes between TGLP and TGL. TGLP is associated with intelligible speech. However, studies investigating gastrostomy tube dependence following TGLP versus TGL have generated conflicting results.

Conclusion: Further research on functional and QOL outcomes in patients undergoing TGL or TGLP is needed.

Keywords: Head and neck cancer; Outcomes; Survival; Total glossectomy; Total laryngectomy.