2D materials-based nanomedicine: From discovery to applications

Jiang Ouyang; Siyuan Rao; Runcong Liu; Liqiang Wang; Wei Chen; Wei Tao; Na Kong

doi:10.1016/j.addr.2022.114268

2D materials-based nanomedicine: From discovery to applications

Adv Drug Deliv Rev. 2022 Jun:185:114268. doi: 10.1016/j.addr.2022.114268. Epub 2022 Apr 8.

Authors

Jiang Ouyang¹, Siyuan Rao², Runcong Liu³, Liqiang Wang⁴, Wei Chen¹, Wei Tao⁵, Na Kong⁶

Affiliations

¹ Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
² Guangzhou University of Chinese Medicine, Guangzhou, China & Orthopedics Department, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510006, China.
³ Zhuhai Hospital Affiliated, Jinan University, Zhuhai, Guangdong 519000, China.
⁴ School of Material Science and Engineering, Zhengzhou University, Zhengzhou, Henan 450001, China.
⁵ Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: wtao@bwh.harvard.edu.
⁶ Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang 311121, China; Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: kongna@zju.edu.cn.

PMID: 35398466
DOI: 10.1016/j.addr.2022.114268

Abstract

Due to their unique physicochemical characteristics, 2D materials have attracted more and more attention in the biomedicine field. Currently, 2D materials-based nanomedicines have been extensively applied in various diseases including cancer, bacterial infection, tissue engineering, biological protection, neurodegenerative diseases, and cardiovascular disease. Depending on their various characteristics, these 2D nanomedicines exert their therapeutic effect in different ways, showing great clinical application prospects. Herein, we focus on the various biomedical applications of 2D materials-based nanomedicine. The structures and characteristics of several typical 2D nanomaterials with different configurations and their corresponding biomedical applications are first introduced. Then, the potential of 2D nanomedicines on therapeutic and imaging and their biological functionalization are discussed. Furthermore, the therapeutic potentials of 2D nanomedicines in various diseases are also comprehensively summarized. At last, the challenges and perspectives for the advancement of 2D nanomedicines in clinical transformation are outlooks.

Keywords: 2D materials; Biomedical applications; Nanomedicine; Nanotechnology.

Publication types

Review

MeSH terms

Humans
Nanomedicine
Nanostructures* / chemistry
Nanostructures* / therapeutic use
Neoplasms* / drug therapy
Tissue Engineering