Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis

Haochuan Liu; Bing Chen; Qingsan Zhu

doi:10.1186/s13036-022-00288-7

Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis

J Biol Eng. 2022 Apr 8;16(1):10. doi: 10.1186/s13036-022-00288-7.

Authors

Haochuan Liu¹, Bing Chen², Qingsan Zhu³

Affiliations

¹ Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Xiantai Street No. 126, Changchun, TX, 130031, PR China.
² Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Xiantai Street No. 126, Changchun, TX, 130031, PR China. Chenbing2020@jlu.edu.cn.
³ Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Xiantai Street No. 126, Changchun, TX, 130031, PR China. zhuqs@jlu.edu.cn.

Abstract

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. This disorder may cause progressive and permanent impairment, placing significant physical and psychological strain on sufferers. Each progress in MS therapy marks a significant advancement in neurological research. Hydrogels can serve as a scaffold with high water content, high expansibility, and biocompatibility to improve MS cell proliferation in vitro and therapeutic drug delivery to cells in vivo. Hydrogels may also be utilized as biosensors to detect MS-related proteins. Recent research has employed hydrogels as an adjuvant imaging agent in immunohistochemistry assays. Following an overview of the development and use of hydrogels in MS diagnostic and therapy, this review discussed hydrogel's advantages and future opportunities in the diagnosis and treatment of MS.

Keywords: Biosensor; Cell culture; Cell delivery; Hydrogel; Multiple sclerosis.

Publication types

Review