Incidence patterns of childhood non-Wilms renal tumors: Comparing data of the Nationwide Registry of Childhood Hematological Malignancies and Solid Tumors (NARECHEM-ST), Greece, and the Surveillance, Epidemiology, and End Results Program (SEER), USA

Dimitrios Doganis; Maria A Karalexi; NARECHEM-ST collaborating group; Paraskevi Panagopoulou; Panagiota Bouka; Evdoxia Bouka; Georgios Markozannes; Evangelia E Ntzani; Eva Steliarova-Foucher; Eleni Th Petridou

doi:10.1016/j.canep.2022.102153

Incidence patterns of childhood non-Wilms renal tumors: Comparing data of the Nationwide Registry of Childhood Hematological Malignancies and Solid Tumors (NARECHEM-ST), Greece, and the Surveillance, Epidemiology, and End Results Program (SEER), USA

Cancer Epidemiol. 2022 Jun:78:102153. doi: 10.1016/j.canep.2022.102153. Epub 2022 Apr 4.

Authors

Dimitrios Doganis¹, Maria A Karalexi²; NARECHEM-ST collaborating group; Paraskevi Panagopoulou¹³, Panagiota Bouka¹³, Evdoxia Bouka¹³, Georgios Markozannes¹⁴, Evangelia E Ntzani¹⁵, Eva Steliarova-Foucher¹⁶, Eleni Th Petridou¹⁷

Collaborators

NARECHEM-ST collaborating group:
Maria Moschovi³, Kondilia Antoniad⁴, Sofia Polychronopoulou⁴, Eugenia Papakonstantinou⁵, Athanasios Tragiannidis⁶, Eleni Vasileiou⁶, Nikolaos Katzilakis⁷, Iordanis Pelagiadis⁷, Helen Dana⁸, Kalliopi Stefanaki⁹, Katerina Strantzia¹⁰, Maria Gavra¹¹, Aikaterini Alexopoulou¹²

Affiliations

¹ Hellenic Society for Social Pediatrics and Health Promotion, Athens, Greece; Department of Pediatric Hematology-Oncology, "P&A Kyriakou" Children's Hospital, Athens, Greece.
² Hellenic Society for Social Pediatrics and Health Promotion, Athens, Greece; Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.
³ Pediatric Hematology-Oncology Unit, 1st Department of Pediatrics, 'A. Sofia' Children's Hospital, Athens, Greece.
⁴ Department of Pediatric Hematology-Oncology, "Agia Sofia" Children's Hospital, Athens, Greece.
⁵ Department of Pediatric Hematology and Oncology, Hippokration Hospital, Thessaloniki, Greece.
⁶ Hematology-Oncology Unit, 2nd Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
⁷ Department of Pediatric Hematology-Oncology, University of Crete, University Hospital of Heraklion, Heraklion, Greece.
⁸ Department of Pediatric and Adolescent Hematology-Oncology 'Mitera' Children's Hospital, Athens, Greece.
⁹ Department of Pathology, Children's Hospital "Agia Sofia", Athens, Greece.
¹⁰ Pathology Laboratory, "P & A Kyriakou" Children's Hospital, Athens, Greece.
¹¹ Department of Paediatric Radiology (CT & MRI) and Nuclear Medicine, 'Aghia Sophia' Children's Hospital, Athens, Greece.
¹² Children's & Adolescents Radiotherapy Department - Athens General Children's Hospital "P. & A. Kyriakou", Athens, Greece.
¹³ Hellenic Society for Social Pediatrics and Health Promotion, Athens, Greece.
¹⁴ Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.
¹⁵ Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece; Center for Evidence Synthesis in Health, Brown University School of Public Health, Providence, RI, USA.
¹⁶ Section of Cancer Surveillance, International Agency for Research on Cancer (IARC), Lyon, France.
¹⁷ Hellenic Society for Social Pediatrics and Health Promotion, Athens, Greece; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: epetrid@med.uoa.gr.

PMID: 35390585
DOI: 10.1016/j.canep.2022.102153

Abstract

Background: We used, for the first time, data registered in the Nationwide Registry for Childhood Hematological Malignancies and Solid Tumors (NARECHEM-ST)-Greece to estimate incidence/time trends of the rare childhood (0-14 years) non-Wilms tumors (non-WT), and compared the results of malignant non-WT to those from the Surveillance, Epidemiology, and End Results Program (SEER)-USA.

Methods: Fifty-five cases (n = 33 malignant-only) were extracted from NARECHEM-ST (2001-2020) and 332 malignant cases from SEER (1990-2017). To allow between-country comparisons, age-standardized incidence rates (AIR) of malignant-only non-WT were calculated, and temporal trends were evaluated using Poisson and joinpoint regressions.

Results: In NARECHEM-ST, malignant and non-malignant non-WT accounted for 22.6% of all renal tumors. Among malignant tumors, the AIR was 1.0/10⁶ children in Greece, similar to that calculated for SEER, USA (AIR=0.9/10⁶). The proportion of infant malignant and non-malignant non-WT was 27% (20% before 6 months) in NARECHEM-ST. Most common non-WT in Greece were congenital mesoblastic nephromas (CMN) diagnosed mainly in infancy (CIR=7.2/10⁶). The proportion of infant malignant non-WT was 20% in SEER (AIR_infancy=2.5/10⁶), mainly attributed to rhabdoid tumors (CIR=1.6/10⁶). The male-to-female (M:F) ratio of malignant non-WT was 0.9 in NARECHEM-ST vs. 1.2 in SEER, whereas boys outnumbered girls with clear cell sarcoma in NARECHEM-ST (M:F=4.0). Lastly, significantly increasing trends in incidence rates were noted in NARECHEM-ST [+ 6.8%, 95% confidence intervals (CI): 0.5, 13.3] and in SEER (+7.3%, 95%CI: 5.6, 9.0).

Conclusions: Observed incidence, time trends and sociodemographic variations of non-WT may reflect differential registration practices and healthcare delivery patterns including differences regarding surveillance, coding and treatment practices.

Keywords: Age differentials; Childhood; Incidence; Non-Wilms renal tumors; Time trends.

MeSH terms

Child
Female
Greece / epidemiology
Hematologic Neoplasms*
Humans
Incidence
Infant
Kidney Neoplasms* / epidemiology
Male
Registries
SEER Program
Wilms Tumor* / epidemiology

Grants and funding

001/WHO_/World Health Organization/International