Immune genes outside immune cells for multiple sclerosis

Na Sun; Manolis Kellis

doi:10.1016/j.neuron.2022.03.017

Immune genes outside immune cells for multiple sclerosis

Neuron. 2022 Apr 6;110(7):1090-1092. doi: 10.1016/j.neuron.2022.03.017.

Authors

Na Sun¹, Manolis Kellis²

Affiliations

¹ MIT Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA.
² MIT Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA. Electronic address: manoli@mit.edu.

PMID: 35390286
DOI: 10.1016/j.neuron.2022.03.017

Abstract

In this issue of Neuron, Meijer and Agirre et al. (2022) demonstrate that immune genes exhibit a primed chromatin state in healthy oligodendroglia and are transcriptionally activated in MS through a series of epigenetic activations including histone modification deposition, transcription factor binding, and chromatin reconfiguration.

Publication types

Comment

MeSH terms

Chromatin / genetics
Chromatin / metabolism
Epigenesis, Genetic
Epigenomics
Humans
Multiple Sclerosis* / genetics
Multiple Sclerosis* / metabolism
Oligodendroglia / metabolism

Substances

Chromatin