Biological Functions and Molecular Mechanisms of MiR-608 in Cancer

Juan Lu; Danhua Zhu; Lanjuan Li

doi:10.3389/fonc.2022.870983

Biological Functions and Molecular Mechanisms of MiR-608 in Cancer

Front Oncol. 2022 Mar 21:12:870983. doi: 10.3389/fonc.2022.870983. eCollection 2022.

Authors

Juan Lu¹, Danhua Zhu¹, Lanjuan Li¹

Affiliation

¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Abstract

In recent years, microRNAs (miRNAs) have attracted much attention because of their prominent role in cancer. An increasing number of studies have shown that miRNAs play an important role in a variety of tumors. miR-608 has been reported to be decreased in cancers, especially in solid tumors. miR-608 is regarded as a tumor suppressor, which has been verified through a large number of experiments both in vivo and in vitro. miR-608 participates in many biological processes, including cell proliferation, invasion, migration, and apoptosis, by inhibiting transmembrane proteins and many signaling pathways. Here, we summarize the expression profile and biological functions and mechanism of miR-608, suggesting that miR-608 is an ideal diagnostic and prognostic biomarker and a treatment target for cancer.

Keywords: biomarker; cancer; miR-608; molecular mechanism; tumor suppressor.

Publication types

Review