Baseline Conservative and Surgical Management in the Treatment of NSAID-Exacerbated Respiratory Disease

Saara Sillanpää; Jura Numminen

doi:10.3389/falgy.2021.659887

Baseline Conservative and Surgical Management in the Treatment of NSAID-Exacerbated Respiratory Disease

Front Allergy. 2021 May 28:2:659887. doi: 10.3389/falgy.2021.659887. eCollection 2021.

Authors

Saara Sillanpää¹, Jura Numminen¹

Affiliation

¹ Department of Ear and Oral Diseases, Tampere University Hospital, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Abstract

Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) is a chronic medical condition that includes asthma, chronic rhinosinusitis with nasal polyposis, and hypersensitivity to aspirin and other NSAIDs. Eosinophilic inflammation in the upper and lower airways is treated with local corticosteroids, repeated antibiotics, oral corticosteroid courses, endoscopic sinus surgery, and in some cases aspirin treatment after desensitization (ATAD). Nevertheless, the disease may be uncontrolled and it has a great impact on quality of life. A better understanding of the pathomechanisms of the disease and the development of medications that target type 2 inflammation mediators may have a crucial role in achieving better disease control in patients with N-ERD.

Keywords: NSAID-exacerbated respiratory disease; aspirin allergy; asthma; chronic rhinosinusitis with nasal polyps; nasal polyps.

Publication types

Review