Lung parenchymal calcifications in a child with cystic fibrosis

Heidi Lynch; Frank Qian; Matthew D Wong; Rahul J Thomas; Nitin Kapur

doi:10.1002/rcr2.941

Lung parenchymal calcifications in a child with cystic fibrosis

Respirol Case Rep. 2022 Mar 31;10(5):e0941. doi: 10.1002/rcr2.941. eCollection 2022 May.

Authors

Heidi Lynch¹, Frank Qian¹, Matthew D Wong^{1

2

3}, Rahul J Thomas^{1

2

3}, Nitin Kapur^{1

2

3}

Affiliations

¹ Department of Pediatric Respiratory and Sleep Medicine Queensland Children's Hospital South Brisbane Queensland Australia.
² Child Health Research Centre University of Queensland South Brisbane Queensland Australia.
³ Children's Health Queensland Clinical Unit, Faculty of Medicine University of Queensland South Brisbane Queensland Australia.

Abstract

We describe a 6-year-old girl with homozygous p.Phe508del cystic fibrosis with severe multi-lobar bronchiectasis and obstructive lung disease who was found to have prominent parenchymal calcifications in the right middle lobe on a computed tomography scan of the chest. Histopathology from the calcified area of lung biopsy showed fibrous tissue with chronic inflammation with CD3+ T-lymphocytes and macrophages with no granulomas. Dystrophic calcification was seen within this necrotic debris.

Keywords: cystic fibrosis; lung calcifications.

Publication types

Case Reports