m6A binding protein YTHDF2 in cancer

Xiaomin Chen; Xiangxiang Zhou; Xin Wang

doi:10.1186/s40164-022-00269-y

m⁶A binding protein YTHDF2 in cancer

Exp Hematol Oncol. 2022 Apr 5;11(1):21. doi: 10.1186/s40164-022-00269-y.

Authors

Xiaomin Chen^{1

2}, Xiangxiang Zhou^{3

4

5

6

7

8}, Xin Wang^{9

10

11

12

13

14}

Affiliations

¹ Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, No.324, Jingwu Road, Jinan, 250021, Shandong, China.
² School of Medicine, Shandong University, Jinan, 250012, Shandong, China.
³ Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, No.324, Jingwu Road, Jinan, 250021, Shandong, China. xiangxiangzhou@sdu.edu.cn.
⁴ Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. xiangxiangzhou@sdu.edu.cn.
⁵ School of Medicine, Shandong University, Jinan, 250012, Shandong, China. xiangxiangzhou@sdu.edu.cn.
⁶ Shandong Provincial Engineering Research Center of Lymphoma, Jinan, 250021, Shandong, China. xiangxiangzhou@sdu.edu.cn.
⁷ Branch of National Clinical Research Center for Hematologic Diseases, Jinan, 250021, Shandong, China. xiangxiangzhou@sdu.edu.cn.
⁸ National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, 251006, China. xiangxiangzhou@sdu.edu.cn.
⁹ Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, No.324, Jingwu Road, Jinan, 250021, Shandong, China. xinw007@126.com.
¹⁰ Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. xinw007@126.com.
¹¹ School of Medicine, Shandong University, Jinan, 250012, Shandong, China. xinw007@126.com.
¹² Shandong Provincial Engineering Research Center of Lymphoma, Jinan, 250021, Shandong, China. xinw007@126.com.
¹³ Branch of National Clinical Research Center for Hematologic Diseases, Jinan, 250021, Shandong, China. xinw007@126.com.
¹⁴ National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, 251006, China. xinw007@126.com.

Abstract

YT521-B homology domain family member 2 (YTHDF2) is an N⁶-methyladenosine (m⁶A)-binding protein that was originally found to regulate the stability of mRNA. Growing evidence has shown that YTHDF2 can participate in multifarious bioprocesses, including embryonic development, immune response, and tumor progression. Furthermore, YTHDF2 is closely associated with the proliferation, apoptosis, invasion, and migration of tumor cells, suggesting its significant role in cancers. YTHDF2 primarily relies on m⁶A modification to modulate signaling pathways in cancer cells. However, the expression and function of YTHDF2 in human malignancies remain controversial. Meanwhile, the underlying molecular mechanisms of YTHDF2 have not been elucidated. In this review, we principally summarized the biological functions and molecular mechanisms of YTHDF2 in tumors and discussed its prognostic and therapeutic values.

Keywords: Cancer; Mechanism; Prognosis; YTHDF2; m6A.

Publication types

Review

Abstract

Publication types

Grants and funding