The Beauty and Complexity of Blood Vessel Patterning

Victoria L Bautch; Yoh-Suke Mukouyama

doi:10.1101/cshperspect.a041167

The Beauty and Complexity of Blood Vessel Patterning

Cold Spring Harb Perspect Med. 2022 Nov 1;12(11):a041167. doi: 10.1101/cshperspect.a041167.

Authors

Victoria L Bautch^{1

2

3}, Yoh-Suke Mukouyama⁴

Affiliations

¹ Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
² McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
³ Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
⁴ Laboratory of Stem Cell and Neuro-Vascular Biology, Cell and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

PMID: 35379659
PMCID: PMC9619359 (available on 2024-11-01)
DOI: 10.1101/cshperspect.a041167

Abstract

This review highlights new concepts in vascular patterning in the last 10 years, with emphasis on its beauty and complexity. Endothelial cell signaling pathways that respond to molecular or mechanical signals are described, and examples of vascular patterning that use these pathways in brain, skin, heart, and kidney are highlighted. The pathological consequences of patterning loss are discussed in the context of arteriovenous malformations (AVMs), and prospects for the next 10 years presented.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Arteriovenous Malformations* / metabolism
Arteriovenous Malformations* / pathology
Brain / metabolism
Humans
Signal Transduction

Abstract

Publication types

MeSH terms

Grants and funding