Structure-Property Relationship for Different Mesoporous Silica Nanoparticles and its Drug Delivery Applications: A Review

Parya Kazemzadeh; Khalil Sayadi; Ali Toolabi; Jalil Sayadi; Malihe Zeraati; Narendra Pal Singh Chauhan; Ghasem Sargazi

doi:10.3389/fchem.2022.823785

Structure-Property Relationship for Different Mesoporous Silica Nanoparticles and its Drug Delivery Applications: A Review

Front Chem. 2022 Mar 14:10:823785. doi: 10.3389/fchem.2022.823785. eCollection 2022.

Authors

Parya Kazemzadeh¹, Khalil Sayadi², Ali Toolabi³, Jalil Sayadi⁴, Malihe Zeraati⁵, Narendra Pal Singh Chauhan⁶, Ghasem Sargazi⁷

Affiliations

¹ Department of Chemistry, Lorestan University, Khorramabad, Iran.
² Department of Chemistry, Young Researchers Society, Shahid Bahonar University of Kerman, Kerman, Iran.
³ Department of Environmental Health Engineering, School of Public Health, Bam University of Medical Sciences, Bam, Iran.
⁴ Department Environmental Engineering, University of Zabol, Zabol, Iran.
⁵ Department of Materials Engineering, Shahid Bahonar University of Kerman, Kerman, Iran.
⁶ Department of Chemistry, Faculty of Science, Bhupal Nobles' University, Udaipur, India.
⁷ Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran.

Abstract

Mesoporous silica nanoparticles (MSNs) are widely used as a promising candidate for drug delivery applications due to silica's favorable biocompatibility, thermal stability, and chemical properties. Silica's unique mesoporous structure allows for effective drug loading and controlled release at the target site. In this review, we have discussed various methods of MSNs' mechanism, properties, and its drug delivery applications. As a result, we came to the conclusion that more in vivo biocompatibility studies, toxicity studies, bio-distribution studies and clinical research are essential for MSN advancement.

Keywords: drug delivery; mesoporous; nanoparticles; properties; silica.

Publication types

Review