Autophagy and Skin Diseases

Kim Klapan; Dagmar Simon; Alexander Karaulov; Marina Gomzikova; Albert Rizvanov; Shida Yousefi; Hans-Uwe Simon

doi:10.3389/fphar.2022.844756

Autophagy and Skin Diseases

Front Pharmacol. 2022 Feb 18:13:844756. doi: 10.3389/fphar.2022.844756. eCollection 2022.

Authors

Kim Klapan¹, Dagmar Simon², Alexander Karaulov³, Marina Gomzikova⁴, Albert Rizvanov⁴, Shida Yousefi¹, Hans-Uwe Simon^{1

3

4

5}

Affiliations

¹ Institute of Pharmacology, University of Bern, Bern, Switzerland.
² Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
³ Department of Clinical Immunology and Allergology, Sechenov University, Moscow, Russia.
⁴ Laboratory of Molecular Immunology, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
⁵ Institute of Biochemistry, Brandenburg Medical School, Neuruppin, Germany.

Abstract

Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles with their enzymes. Autophagy is widely known for its function in cellular homeostasis under physiological and pathological settings. Defects in autophagy have been implicated in the pathophysiology of a variety of human diseases. The new line of evidence suggests that autophagy is inextricably linked to skin disorders. This review summarizes the principles behind autophagy and highlights current findings of autophagy's role in skin disorders and strategies for therapeutic modulation.

Keywords: atopic dermatitis; autophagy; inflammation; psoriasis; skin cancer.

Publication types

Review