TRPM2 Plays a Minor Role in AKI and Kidney Fibrosis

Yu Kurata; Tetsuhiro Tanaka; Hana Cernecka; Frank Eitner; Masaomi Nangaku

doi:10.34067/KID.0005492021

TRPM2 Plays a Minor Role in AKI and Kidney Fibrosis

Kidney360. 2021 Oct 22;3(1):153-157. doi: 10.34067/KID.0005492021. eCollection 2022 Jan 27.

Authors

Yu Kurata¹, Tetsuhiro Tanaka¹, Hana Cernecka², Frank Eitner², Masaomi Nangaku¹

Affiliations

¹ Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan.
² Research and Development, Bayer AG, Pharmaceuticals, Wuppertal, Germany.

Abstract

TRPM2 is a Ca2⁺-permeable cationic channel and serves as an oxidative stress sensor.TRPM2 deletion was harmful in renal ischemia-reperfusion injury, whereas TRPM2 deletion mitigated kidney fibrosis.Our findings suggest the role of TRPM2 in kidney diseases is context dependent.

Keywords: TRPM2; acute kidney injury; acute kidney injury and ICU nephrology; basic science; chronic kidney disease; fibrosis; ischemia-reperfusion injury.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acute Kidney Injury* / etiology
Fibrosis
Humans
Kidney / pathology
Reperfusion Injury* / genetics
TRPM Cation Channels* / genetics

Substances

TRPM Cation Channels
TRPM2 protein, human