Time versus tissue: Timely identification of Scedosporium Rhinosinusitis in a post-COVID-19 case by MALDI-TOF MS leading to successful management

Preeti Rai; Anup Kumar Singh; Kavita Bala Anand; Sanjay Pratap Singh; Kapil Tomar

doi:10.1016/j.mjafi.2022.01.014

Time versus tissue: Timely identification of Scedosporium Rhinosinusitis in a post-COVID-19 case by MALDI-TOF MS leading to successful management

Med J Armed Forces India. 2022 Jul;78(3):360-364. doi: 10.1016/j.mjafi.2022.01.014. Epub 2022 Mar 28.

Authors

Preeti Rai¹, Anup Kumar Singh², Kavita Bala Anand³, Sanjay Pratap Singh⁴, Kapil Tomar⁵

Affiliations

¹ Resident, Department of Microbiology, Armed Forces Medical College, Pune, India.
² Resident, Department of Oral Maxillo Facial Surgery, Armed Forces Medical College, Pune, India.
³ Associate Professor, Department of Microbiology, Armed Forces Medical College, Pune, India.
⁴ Professor & Head, Department of Microbiology, Armed Forces Medical College, Pune, India.
⁵ Associate Professor, Department of Oral Maxillo Facial Surgery, Armed Forces Medical College, Pune, India.

Abstract

COVID-19 (Coronavirus Disease 2019), illness with associated comorbidities and corticosteroid therapy makes the host immunocompromised and prone to opportunistic microbial infections. As the world continues to struggle with the pandemic of COVID-19, an increase in cases of opportunistic fungal infections have been reported from all over the world during the second wave of COVID-19 like aspergillosis, mucormycosis, and candidiasis. Scedosporium apiospermum is an emerging pathogen that is usually associated with mycetoma, pulmonary infection, and central nervous infections. It has been rarely associated with fungal rhinosinusitis (FRS). In this study, a rare case of FRS caused by S.apiospermum in an immunocompromised post-Covid-19 diabetic woman is reported.

Keywords: Fungal rhinosinusitis; MALDI-TOF/MS; Posaconazole; Scedosporium apiospermum.

Publication types

Case Reports