Comprehensive proteomic profiling of serum extracellular vesicles in patients with colorectal liver metastases identifies a signature for non-invasive risk stratification and early-response evaluation

Kuailu Lin; Franziska Baenke; Xixi Lai; Martin Schneider; Dominic Helm; Heike Polster; Venkatesh S Rao; Nicole Ganig; Fang Cheng Wong; Lena Seifert; Adrian M Seifert; Beatrix Jahnke; Nicole Kretschmann; Tjalf Ziemssen; Fee Klupp; Thomas Schmidt; Martin Schneider; Yi Han; Tim F Weber; Verena Plodeck; Heiner Nebelung; Nathalie Schmitt; Felix Korell; Bruno C Köhler; Carina Riediger; Jürgen Weitz; Nuh N Rahbari; Christoph Kahlert

doi:10.1186/s12943-022-01562-4

Comprehensive proteomic profiling of serum extracellular vesicles in patients with colorectal liver metastases identifies a signature for non-invasive risk stratification and early-response evaluation

Mol Cancer. 2022 Apr 1;21(1):91. doi: 10.1186/s12943-022-01562-4.

Authors

Kuailu Lin^#^{1

2}, Franziska Baenke^#^{1

3}, Xixi Lai^{1

4}, Martin Schneider⁵, Dominic Helm⁵, Heike Polster¹, Venkatesh S Rao¹, Nicole Ganig^{1

3}, Fang Cheng Wong¹, Lena Seifert^{1

3

6}, Adrian M Seifert^{1

3

6}, Beatrix Jahnke¹, Nicole Kretschmann⁷, Tjalf Ziemssen⁷, Fee Klupp⁸, Thomas Schmidt^{8

9}, Martin Schneider⁸, Yi Han¹, Tim F Weber¹⁰, Verena Plodeck¹¹, Heiner Nebelung¹¹, Nathalie Schmitt¹², Felix Korell^{12

13}, Bruno C Köhler^{12

14}, Carina Riediger¹, Jürgen Weitz^{1

3

6}, Nuh N Rahbari^#¹⁵, Christoph Kahlert^#^{16

17

18}

Affiliations

¹ Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
² Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
³ German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Dresden, Heidelberg, Germany.
⁴ Department of Respiratory and Critical Care Medicine, College of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
⁵ MS-Based Protein Analysis Unit, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
⁶ National Center for Tumor Diseases (NCT/UCC), Partner Site Dresden, Heidelberg, Germany.
⁷ MS Center, Centre of Clinical Neuroscience, Department of Neurology, Carl Gustav Carus University Hospital Dresden, Dresden, Germany.
⁸ Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.
⁹ Klinik Für Allgemein, Viszeral-, Tumor- Und Transplantationschirurgie, Universitätklinikum Köln, Kerpener Str. 62, 50937, Köln, Germany.
¹⁰ Diagnostic and Interventional Radiology (DiR), Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.
¹¹ Department of Diagnostic and Interventional Radiology, Carl Gustav Carus University Hospital Dresden, Dresden, Germany.
¹² Department of Medical Oncology, National Center for Tumour Diseases, Liver Cancer Centre Heidelberg, University Hospital Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
¹³ Department of Medicine V, University of Heidelberg, Heidelberg, Germany.
¹⁴ German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.
¹⁵ Department of Surgery, Medical Faculty Mannheim, University Medicine Mannheim, University of Heidelberg, 68167, Mannheim, Germany. nuh.rahbari@umm.de.
¹⁶ Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany. Christoph.Kahlert@uniklinikum-dresden.de.
¹⁷ German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Dresden, Heidelberg, Germany. Christoph.Kahlert@uniklinikum-dresden.de.
¹⁸ National Center for Tumor Diseases (NCT/UCC), Partner Site Dresden, Heidelberg, Germany. Christoph.Kahlert@uniklinikum-dresden.de.

^# Contributed equally.

No abstract available

Keywords: Colorectal liver metastases; Early response prediction; Extracellular vesicles; Molecular risk stratification; Protein signature.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Colorectal Neoplasms* / genetics
Colorectal Neoplasms* / pathology
Extracellular Vesicles*
Humans
Liver Neoplasms* / secondary
Proteomics
Risk Assessment