Fast and versatile alteration of focal positions is critical for applications including selective volumetric modification and parallel laser processing. In this Letter, we implement and characterize an ultrafast, variable focal system using a tunable acoustic gradient of index lens to achieve multi-focal laser processing. We apply our method to the femtosecond laser-induced intra-volumetric modification in glass to show the flexibility in controlling focal positions. Based on this understanding, we exploit the multi-focal nature of the system to demonstrate laser machining on both surfaces of a transparent glass slide in a single lateral scan.