Association Between SARS-CoV-2 Viral Load in Wastewater and Reported Cases, Hospitalizations, and Vaccinations in Milan, March 2020 to November 2021

Giovanni Nattino; Sara Castiglioni; Danilo Cereda; Petra Giulia Della Valle; Laura Pellegrinelli; Guido Bertolini; Elena Pariani

doi:10.1001/jama.2022.4908

Association Between SARS-CoV-2 Viral Load in Wastewater and Reported Cases, Hospitalizations, and Vaccinations in Milan, March 2020 to November 2021

JAMA. 2022 May 17;327(19):1922-1924. doi: 10.1001/jama.2022.4908.

Authors

Giovanni Nattino¹, Sara Castiglioni², Danilo Cereda³, Petra Giulia Della Valle⁴, Laura Pellegrinelli⁵, Guido Bertolini¹, Elena Pariani⁵

Affiliations

¹ Department of Public Health, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica, Italy.
² Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
³ Directorate General for Health, Lombardy Region, Milan, Italy.
⁴ Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
⁵ Department of Biomedical Sciences for Health, University of Milan, Milano, Italy.

Abstract

This study evaluates the association between SARS-CoV-2 load in urban wastewater and surveillance indicators of infection prevalence and severity in Milan, Italy.

MeSH terms

COVID-19* / epidemiology
COVID-19* / virology
Hospitalization / statistics & numerical data
Humans
Italy / epidemiology
RNA, Viral / isolation & purification
SARS-CoV-2* / isolation & purification
Vaccination / statistics & numerical data
Viral Load* / statistics & numerical data
Wastewater* / analysis
Wastewater* / virology

Substances

RNA, Viral
Waste Water