MicroRNAs/LncRNAs Modulate MDSCs in Tumor Microenvironment

Xiaocui Liu; Shang Zhao; Hongshu Sui; Hui Liu; Minhua Yao; Yanping Su; Peng Qu

doi:10.3389/fonc.2022.772351

MicroRNAs/LncRNAs Modulate MDSCs in Tumor Microenvironment

Front Oncol. 2022 Mar 14:12:772351. doi: 10.3389/fonc.2022.772351. eCollection 2022.

Authors

Xiaocui Liu¹, Shang Zhao², Hongshu Sui¹, Hui Liu¹, Minhua Yao¹, Yanping Su¹, Peng Qu^{1

3}

Affiliations

¹ Department of Histology and Embryology, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, China.
² Department of Pathophysiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, China.
³ National Institutes of Health (NIH), Bethesda, MD, United States.

Abstract

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature cells derived from bone marrow that play critical immunosuppressive functions in the tumor microenvironment (TME), promoting cancer progression. According to base length, Non-coding RNAs (ncRNAs) are mainly divided into: microRNAs (miRNAs), lncRNAs, snRNAs and CircRNAs. Both miRNA and lncRNA are transcribed by RNA polymerase II, and they play an important role in gene expression under both physiological and pathological conditions. The increasing data have shown that MiRNAs/LncRNAs regulate MDSCs within TME, becoming one of potential breakthrough points at the investigation and treatment of cancer. Therefore, we summarize how miRNAs/lncRNAs mediate the differentiation, expansion and immunosuppressive function of tumor MDSCs in TME. We will then focus on the regulatory mechanisms of exosomal MicroRNAs/LncRNAs on tumor MDSCs. Finally, we will discuss how the interaction of miRNAs/lncRNAs modulates tumor MDSCs.

Keywords: lncRNAs; microRNAs; myeloid-derived suppressor cells; networks; tumor microenvionment.

Publication types

Review