Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Manzar Alam; Sarfraz Ahmed; Abdelbaset Mohamed Elasbali; Mohd Adnan; Shoaib Alam; Md Imtaiyaz Hassan; Visweswara Rao Pasupuleti

doi:10.3389/fonc.2022.860508

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Front Oncol. 2022 Mar 10:12:860508. doi: 10.3389/fonc.2022.860508. eCollection 2022.

Authors

Manzar Alam¹, Sarfraz Ahmed², Abdelbaset Mohamed Elasbali³, Mohd Adnan⁴, Shoaib Alam⁵, Md Imtaiyaz Hassan¹, Visweswara Rao Pasupuleti^{6

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Affiliations

¹ Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
² Department of Biosciences, Jamia Millia Islamia, New Delhi, India.
³ Department of Clinical Laboratory Science, College of Applied Sciences-Qurayyat, Jouf University, Sakakah, Saudi Arabia.
⁴ Department of Biology, College of Science, University of Hail, Hail, Saudi Arabia.
⁵ Department of Biotechnology, Jamia Millia Islamia, New Delhi, India.
⁶ Department of Biomedical Sciences and Therapeutics, Faculty of Medicine & Health Sciences, University Malaysia Sabah, Kota Kinabalu, Malaysia.
⁷ Department of Biochemistry, Faculty of Medicine and Health Sciences, Abdurrab University, Pekanbaru, Indonesia.
⁸ Centre for International Collaboration and Research, Reva University, Rukmini Knowledge Park, Kattigenahalli, Bangalore, India.

Abstract

Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties. CA possesses various biological and pharmacological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. The potential therapeutic effects of CA are mediated via repression and inhibition of transcription and growth factors. CA possesses potential anticancer and neuroprotective effects in human cell cultures and animal models. However, the biomolecular interactions and pathways of CA have been described highlighting the target binding proteins and signaling molecules. The current review focuses on CA's chemical, physical, and pharmacological properties, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. We further described CA's characteristics and therapeutic potential and its future directions.

Keywords: caffeic acid; clinical trials; diabetic neuropathy; inflammatory diseases; inhibitors; targeted therapy.

Publication types

Review