Facile Green Synthesis of Titanium Dioxide Nanoparticles by Upcycling Mangosteen (Garcinia mangostana) Pericarp Extract

Abstract

In the present report, green synthesis of titanium dioxide nanoparticles (TiO₂ NPs) was performed by upcycling mangosteen (Garcinia mangostana) pericarp extract (methanol and ethyl acetate extracts). Field emission scanning electron microscopy images revealed an aggregated structure with a highly porous network of TiO₂ NPs. TiO₂ NPs synthesized with ethyl acetate extract (EtOAc-TiO₂ NPs) exhibited more monodispersity and possessed smoother surfaces than the control TiO₂ NPs (Con-TiO₂ NPs) and TiO₂ NPs synthesized with methanol extract (MeOH-TiO₂ NPs). High-resolution X-ray diffraction patterns clearly confirmed that TiO₂ NPs had a crystalline nature. A mixture of anatase and rutile was observed in Con-TiO₂ NPs and MeOH-TiO₂ NPs, while EtOAc-TiO₂ NPs had only anatase with the smallest size (12.50 ± 1.81 nm). Ethyl acetate extract contained the highest amount of α-mangostin; thus, the surface of TiO₂ NPs was functionalized with ethyl acetate extract. The functionalized TiO₂ NPs synthesized with ethyl acetate extract (EtOAc-TiO₂-αm) showed the highest 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl (DPPH) radical scavenging activity. In vitro cell viability on mouse fibroblast cells (NIH3T3) indicated that the newly synthesized TiO₂ NPs did not show any significant cytotoxicity. Therefore, the TiO₂ NPs in the present report have the potential to be used in cosmetic applications such as sunscreens.

Keywords: Anatase; Garcinia mangostana; Green synthesis; NIH3T3 cells; Rutile; Titanium dioxide.