Impact of a Mediterranean diet on hepatic and metabolic outcomes in non-alcoholic fatty liver disease: The MEDINA randomised controlled trial

Elena S George; Anjana Reddy; Amanda J Nicoll; Marno C Ryan; Catherine Itsiopoulos; Gavin Abbott; Nathan A Johnson; Siddharth Sood; Stuart K Roberts; Audrey C Tierney

doi:10.1111/liv.15264

Impact of a Mediterranean diet on hepatic and metabolic outcomes in non-alcoholic fatty liver disease: The MEDINA randomised controlled trial

Liver Int. 2022 Jun;42(6):1308-1322. doi: 10.1111/liv.15264. Epub 2022 Apr 26.

Authors

Elena S George^{1

2}, Anjana Reddy², Amanda J Nicoll³, Marno C Ryan⁴, Catherine Itsiopoulos^{2

5}, Gavin Abbott¹, Nathan A Johnson⁶, Siddharth Sood⁷, Stuart K Roberts^{8

9}, Audrey C Tierney^{2

10}

Affiliations

¹ Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
² School of Allied Health, Human Services and Sport, La Trobe University, Australia.
³ Department of Gastroenterology, Eastern Health, Box Hill, Australia.
⁴ Department of Gastroenterology and Hepatology, St Vincent's Hospital, Fitzroy, Australia.
⁵ School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.
⁶ The Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, Sydney, New South Wales, Australia.
⁷ Department of Gastroenterology, Melbourne Health, Melbourne, Australia.
⁸ Department of Gastroenterology, Alfred Health, Prahran, Australia.
⁹ Central Clinical School, Monash University, Clayton, Australia.
¹⁰ School of Allied Health, Health Implementation Science and Technology Centre, Health Research Institute, University of Limerick, Ireland.

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is predominantly managed by lifestyle intervention, in the absence of effective pharmacotherapies. Mediterranean diet (MedDiet) is the recommended diet, albeit with limited evidence.

Aims: To compare an ad libitum MedDiet to low-fat diet (LFD) in patients with NAFLD for reducing intrahepatic lipids (IHL) by proton magnetic resonance spectroscopy (¹ H-MRS). Secondary outcomes include insulin resistance by homeostatic model of assessment (HOMA-IR), visceral fat by bioelectrical impedance analysis (BIA), liver stiffness measurement (LSM) and other metabolic outcomes.

Methods: In this parallel multicentre RCT, subjects were randomised (1:1) to MedDiet or LFD for 12 weeks.

Results: Forty-two participants (25 females [60%], mean age 52.3 ± 12.6 years) were included, 23 randomised to LFD and 19 to MedDiet.; 39 completed the study. Following 12 weeks, there were no between-group differences. IHL improved significantly within the LFD group (-17% [log scale]; p = .02) but not within the MedDiet group (-8%, p = .069). HOMA-IR reduced in the LFD group (6.5 ± 5.6 to 5.5 ± 5.5, p < .01) but not in the MedDiet group (4.4 ± 3.2 to 3.9 ± 2.3, p = .07). No differences were found for LSM (MedDiet 7.8 ± 4.0 to 7.6 ± 5.2, p = .429; LFD 11.8 ± 14.3 to 10.8 ± 10.2 p = .99). Visceral fat reduced significantly in both groups; LFD (-76% [log scale], p = <.0005), MedDiet (-61%, p = <.0005).

Conclusions: There were no between-group differences for hepatic and metabolic outcomes when comparing MedDiet to LFD. LFD improved IHL and insulin resistance. Significant improvements in visceral fat were seen within both groups. This study highlights provision of dietary interventions in free-living adults with NAFLD is challenging.

Keywords: Mediterranean diet; dietary patterns; intrahepatic lipids; low-fat diet; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Diet, Fat-Restricted
Diet, Mediterranean*
Female
Humans
Insulin Resistance*
Liver / pathology
Middle Aged
Non-alcoholic Fatty Liver Disease* / pathology