Roles of lncRNAs Mediating Wnt/β-Catenin Signaling in HCC

Yating Xu; Xiao Yu; Zongzong Sun; Yuting He; Wenzhi Guo

doi:10.3389/fonc.2022.831366

Roles of lncRNAs Mediating Wnt/β-Catenin Signaling in HCC

Front Oncol. 2022 Mar 9:12:831366. doi: 10.3389/fonc.2022.831366. eCollection 2022.

Authors

Yating Xu^{1

2

3

4}, Xiao Yu^{1

2

3

4}, Zongzong Sun⁵, Yuting He^{1

2

3

4}, Wenzhi Guo^{1

2

3

4}

Affiliations

¹ Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
³ Open and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, China.
⁴ Zhengzhou Key Laboratory of Hepatobiliary & Pancreatic Diseases and Organ Transplantation Medicine, Zhengzhou, China.
⁵ Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Abstract

Hepatocellular carcinoma (HCC) is considered the second most deadly cancer worldwide. Due to the absence of early diagnostic markers and effective therapeutic approaches, distant metastasis and increasing recurrence rates are major difficulties in the clinical treatment of HCC. Further understanding of its pathogenesis has become an urgent goal in HCC research. Recently, abnormal expression of long noncoding RNAs (lncRNAs) was identified as a vital regulator involved in the initiation and development of HCC. Activation of the Wnt/β-catenin pathway has been reported to obviously impact cell proliferation, invasion, and migration of HCC. This article reviews specific interactions, significant mechanisms and molecules related to HCC initiation and progression to provide promising strategies for treatment.

Keywords: Wnt pathway; biomarker; hepatocellular carcinoma; long noncoding RNA; prognosis.

Publication types

Review