Pregnancy and Delivery Management With Recombinant Factor VIIa in a Glanzmann Thrombasthenia Patient: A Case Report

Leonardo Enciso; Rafael L Aragón-Mendoza; Laura A León; Carrie G Torres-Torres

doi:10.7759/cureus.22570

Pregnancy and Delivery Management With Recombinant Factor VIIa in a Glanzmann Thrombasthenia Patient: A Case Report

Cureus. 2022 Feb 24;14(2):e22570. doi: 10.7759/cureus.22570. eCollection 2022 Feb.

Authors

Leonardo Enciso^{1

2}, Rafael L Aragón-Mendoza³, Laura A León⁴, Carrie G Torres-Torres⁴

Affiliations

¹ Hematology, Hospital Universitario Nacional de Colombia, Bogotá, COL.
² Hematology, Hospital Universitario de La Samaritana, Bogotá, COL.
³ Maternal-fetal medicine, Hospital Universitario de La Samaritana, Bogotá , COL.
⁴ Internal Medicine, Fundación Universitaria Juan N. Corpas, Bogotá, COL.

Abstract

The management of pregnancy and delivery in patients with Glanzmann thrombasthenia requires platelet transfusion and recombinant activated factor VII. We report two successful pregnancies in a single patient and propose a protocol for monitoring and treatment. The urgent need for controlled trials and other epidemiological studies is also underscored.

Keywords: glanzmann thrombasthenia; platelet refractoriness; platelet transfusion; pregnancy; recombinant activated factor vii.

Publication types

Case Reports