Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia

Arvind Sehgal; Kristy Elsayed; Matilda Nugent; Suraj Varma

doi:10.1038/s41372-022-01372-y

Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia

J Perinatol. 2022 Jun;42(6):775-780. doi: 10.1038/s41372-022-01372-y. Epub 2022 Mar 30.

Authors

Arvind Sehgal^{1

2}, Kristy Elsayed³, Matilda Nugent⁴, Suraj Varma⁵

Affiliations

¹ Monash Newborn, Monash Children's Hospital, Melbourne, Australia. Arvind.Sehgal@monash.edu.
² Department of Paediatrics, Monash University, Melbourne, Australia. Arvind.Sehgal@monash.edu.
³ Monash Newborn, Monash Children's Hospital, Melbourne, Australia.
⁴ Department of Paediatrics, Monash University, Melbourne, Australia.
⁵ MonashHeart, Monash Health, Melbourne, Australia.

Abstract

Objectives: To ascertain correlation between systemic hypertension and respiratory sequelae amongst infants with BPD.

Study design: Retrospective evaluation of six-year data compared infants with severe BPD to infants with no BPD. 7-day morning blood pressure (BP) (36⁰-36⁶ week) was compared with 95th centile cut-offs.

Results: 57 infants with BPD were compared with 114 infants with no BPD. Gestation and birthweight were comparable (median [interquartile range], (27 [25, 28] vs. 26.5 weeks [25, 28], p = 0.7 and 706 g [611, 884] vs. 730 [630, 895]), p = 0.1. Number of infants having BP ≥ 95th centile was significantly higher in BPD cohort (systolic BP, 23/57 [40.3%] vs. 3/114 [2.6%], p < 0.001 & mean arterial BP, 26/57 [46%] vs. 3/114 [2.6%], p < 0.001). Amongst BPD infants, higher BP was associated with longer duration of respiratory support (median [range], 109 days [81-138] vs. 87 [58-109], p < 0.001).

Conclusions: Infants with severe BPD had higher BP compared to those without BPD.

MeSH terms

Bronchopulmonary Dysplasia*
Gestational Age
Humans
Hypertension* / complications
Infant
Infant, Newborn
Infant, Very Low Birth Weight
Retrospective Studies