Venous Congestion and Systemic Hypoperfusion in Cardiorenal Syndrome: Two Sides of the Same Coin

Riccardo Scagliola; Claudio Brunelli

doi:10.31083/j.rcm2303111

Venous Congestion and Systemic Hypoperfusion in Cardiorenal Syndrome: Two Sides of the Same Coin

Rev Cardiovasc Med. 2022 Mar 19;23(3):111. doi: 10.31083/j.rcm2303111.

Authors

Riccardo Scagliola¹, Claudio Brunelli¹

Affiliation

¹ Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.

PMID: 35345278
DOI: 10.31083/j.rcm2303111

Abstract

A wide range of comorbidities play a pivotal role in worsening outcomes and increasing mortality risk in patients with heart failure (HF). Among them, renal dysfunction has been recognized as a highly prevalent prognostic variable, with a strong impact on prognosis, length of hospital stay and need for intensive care. In this context, recent evidence has pointed out the relevance of both systemic hypoperfusion and venous congestion on the imbalance of renal function as well as on the conditioning the pathophysiological crosstalk between heart and kidneys through a wide range of haemodynamic and biochemical pathways. This narrative review aims to investigate the intricate interplay between impaired systemic perfusion and venous congestion in cardiorenal syndrome, as well as their haemodynamic and biochemical implications for renal damage in HF.

Keywords: cardiorenal syndrome; heart failure; systemic hypoperfusion; venous congestion.

Publication types

Review

MeSH terms

Cardio-Renal Syndrome* / diagnosis
Cardio-Renal Syndrome* / therapy
Female
Heart Failure* / diagnosis
Heart Failure* / therapy
Hemodynamics
Humans
Hyperemia*
Kidney
Male