Multimodal Imaging-Guided Photothermal Immunotherapy Based on a Versatile NIR-II Aggregation-Induced Emission Luminogen

Dingyuan Yan; Miao Wang; Qian Wu; Niu Niu; Meng Li; Ruixiang Song; Jie Rao; Miaomiao Kang; Zhijun Zhang; Feifan Zhou; Dong Wang; Ben Zhong Tang

doi:10.1002/anie.202202614

Multimodal Imaging-Guided Photothermal Immunotherapy Based on a Versatile NIR-II Aggregation-Induced Emission Luminogen

Angew Chem Int Ed Engl. 2022 Jul 4;61(27):e202202614. doi: 10.1002/anie.202202614. Epub 2022 May 5.

Authors

Dingyuan Yan^{1

2}, Miao Wang³, Qian Wu⁴, Niu Niu^{1

2}, Meng Li^{1

2}, Ruixiang Song³, Jie Rao³, Miaomiao Kang¹, Zhijun Zhang¹, Feifan Zhou³, Dong Wang¹, Ben Zhong Tang⁴

Affiliations

¹ Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.
² Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
³ Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, 570100, China.
⁴ School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, 2001 Longxiang Boulevard, Longgang District, Shenzhen City, Guangdong, 518172, China.

PMID: 35344252
DOI: 10.1002/anie.202202614

Abstract

Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation-induced emission, namely TPA-BT-DPTQ, was designed and prepared based on benzo[c]thiophene unit as a building block; it can be used for simultaneous fluorescence imaging (FLI) in the second near-infrared (NIR-II) window, photoacoustic imaging (PAI), photothermal imaging (PTI), and thermal eradication of tumors. Further experiments validate that photothermal therapy (PTT) mediated by TPA-BT-DPTQ nanoparticles not only destroys the primary tumor but also enhances immunogenicity for further suppressing the growth of tumors at distant sites. Furthermore, PTT combining a programmed death-ligand 1 (PD-L1) antibody prevents the metastasis and recurrence of cancer by potentiating the effect of immunotherapy.

Keywords: Aggregation-Induced Emission; Immunogenic Cell Death; Immunotherapy; NIR-II Emission; Photothermal Therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Humans
Immunotherapy
Multimodal Imaging
Nanoparticles* / therapeutic use
Neoplasms* / diagnostic imaging
Neoplasms* / pathology
Neoplasms* / therapy
Photoacoustic Techniques* / methods
Phototherapy / methods
Theranostic Nanomedicine / methods