Cytotoxicity evaluation of environmentally friendly synthesis Copper/Zinc bimetallic nanoparticles on MCF-7 cancer cells

Firoozeh Abolhasani Zadeh; Dmitry Olegovich Bokov; Omar Dheyauldeen Salahdin; Walid Kamal Abdelbasset; Mohammed Abed Jawad; Mustafa M Kadhim; Maytham T Qasim; Hamzah H Kzar; Moaed E Al-Gazally; Yasser Fakri Mustafa; M Khatami

doi:10.1007/s12210-022-01064-x

Cytotoxicity evaluation of environmentally friendly synthesis Copper/Zinc bimetallic nanoparticles on MCF-7 cancer cells

Rend Lincei Sci Fis Nat. 2022;33(2):441-447. doi: 10.1007/s12210-022-01064-x. Epub 2022 Mar 21.

Authors

Affiliations

¹ Department of Surgery, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
² Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., Bldg. 2, Moscow, 119991 Russian Federation.
³ Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow, 109240 Russian Federation.
⁴ Department Al-Maarif University College, Medical Laboratory Techniques, Anbar-Ramadi, Iraq.
⁵ Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia.
⁶ Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt.
⁷ Al-Nisour University College, Baghdad, Iraq.
⁸ Department of Dentistry, Kut University College, Kut, Wasit 52001 Iraq.
⁹ College of technical engineering, The Islamic University, Najaf, Iraq.
¹⁰ Department of Pharmacy, Osol Aldeen University College, Baghdad, Iraq.
¹¹ Department of Anesthesia, College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq.
¹² Department of Chemistry, College of Veterinary Medicine, Al-Qasim Green University, Al-Qasim, Iraq.
¹³ College of medicine, University of Al-Ameed, Karbala, Iraq.
¹⁴ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001 Iraq.
¹⁵ Department of Environment of Kerman, The Environmental Researches Center, Kerman, Iran.

Abstract

Bimetallic nanoparticles offer unique chemical, physical and optical properties that are not available for monometallic nanoparticles. Bimetallic nanoparticles play a major role in various therapeutic, industrial and energy fields. Recently, nanoparticles of Copper/Zinc bimetallic nanoparticles have attracted attention in various fields, especially medicine. In this study, bimetallic CuO/ZnO nanostructures were biosynthesized using plant extracts. The plant-mediated synthesis nanoparticles were characterized by Transmission electron microscopy (TEM), X-ray diffraction analysis (XRD), Field Emission Scanning Electron Microscopy (FESEM) and Energy-Dispersive Spectroscopy (EDAX). The cytotoxicity of plant-mediated synthesis bimetallic nanoparticles and the synergistic effects of these nanoparticles in combination with the anticancer drug doxorubicin on MCF-7 cancer cells were evaluated by MTT assay.

Keywords: Copper/Zinc bimetallic nanoparticle; Cytotoxicity; Environmentally friendly; MCF-7 cancer cells; MTT assay.