Review on the Synthesis and Therapeutic Potential of Pyrido[2,3- d], [3,2- d], [3,4- d] and [4,3- d]pyrimidine Derivatives

Joana F Campos; Thierry Besson; Sabine Berteina-Raboin

doi:10.3390/ph15030352

Review on the Synthesis and Therapeutic Potential of Pyrido[2,3- d], [3,2- d], [3,4- d] and [4,3- d]pyrimidine Derivatives

Pharmaceuticals (Basel). 2022 Mar 14;15(3):352. doi: 10.3390/ph15030352.

Authors

Joana F Campos¹, Thierry Besson², Sabine Berteina-Raboin¹

Affiliations

¹ Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans CNRS, ICOA UMR 7311, BP 6759, Rue de Chartres, CEDEX 2, 45067 Orléans, France.
² Université de Rouen-Normandie (UNIROUEN), INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France.

Abstract

The objective of this review is to list the structures composed of a pyridopyrimidine moiety which have shown a therapeutic interest or have already been approved for use as therapeutics. We consider all the synthetic protocols to prepare these pyridopyrimidine derivatives. The review is organized into four sections, successively pyrido[2,3-d]pyrimidines, pyrido[3,4-d]pyrimidines, pyrido[4,3-d]pyrimidines and pyrido[3,2-d]pyrimidines. For each compound we present the biological activity and the synthetic route reported. To produce this manuscript, the bibliographic research was done using Reaxys and Scifinder for each kind of pyridopyrimidine.

Keywords: N-heterocycles; biological activity; pyridopyrimidines; synthesis.

Publication types

Review