Structural color has been regarded as an ideal alternative to pigments because of the advantages of environmental friendliness, resistance to fading, and dynamic regulation. Responsive structural color can give real-time visible feedback to external stimuli and thus has great prospects in many applications, such as displays, sensing, anticounterfeiting, information storage, and healthcare monitoring. In this Perspective, we elucidate basic concepts, controllable fabrications, and promising applications of responsive structural colors. In particular, we systematically summarize the general regulation mode of all kinds of responsive structural color systems. First, we introduce the basic chromogenic structures as well as the regulation modes of responsive structural color. Second, we present the fabrication methods of patterned structural color. Then, the promising applications of responsive structural color systems are highlighted in detail. Finally, we present the existing challenges and future perspectives on responsive structural colors.