Cubic Iron Core-Shell Nanoparticles Functionalized to Obtain High-Performance MRI Contrast Agents

Maria Volokhova; Anna Shugai; Masahiko Tsujimoto; Anna-Liisa Kubo; Sven Telliskivi; Mait Nigul; Peep Uudeküll; Heiki Vija; Olesja M Bondarenko; Jasper Adamson; Anne Kahru; Raivo Stern; Liis Seinberg

doi:10.3390/ma15062228

Cubic Iron Core-Shell Nanoparticles Functionalized to Obtain High-Performance MRI Contrast Agents

Materials (Basel). 2022 Mar 17;15(6):2228. doi: 10.3390/ma15062228.

Authors

Affiliations

¹ National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia.
² Department of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.
³ Institute for Integrated Cell-Materials Sciences, Kyoto University, Yoshida-Ushinomiyacho, Sakyo-ku, Kyoto 606-8501, Japan.
⁴ North Estonia Medical Centre, 19 J. Sütiste tee, 13419 Tallinn, Estonia.
⁵ The Radiology Clinic of Tartu University Hospital, 1a L. Puusepa St., 50406 Tartu, Estonia.

Abstract

Nanoparticles with SiO2 coating were synthesized to have a cubic iron core. These were found to have saturation magnetization very close to the highest possible value of any iron-containing nanoparticles and the bulk iron saturation magnetization. The in vitro toxicology studies show that they are highly biocompatible and possess better MRI contrast agent potential than iron oxide NPs.

Keywords: MRI contrast agents; ROS; magnetic properties; nanomaterials; synthesis; toxicity.

Abstract

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