Characterization of PCLO Gene in Amazonian Native American Populations

Amanda de Nazaré Cohen-Paes; Darlen Cardoso de Carvalho; Lucas Favacho Pastana; Elizabeth Ayres Fragoso Dobbin; Fabiano Cordeiro Moreira; Tatiane Piedade de Souza; Marianne Rodrigues Fernandes; Diana Feio da Veiga Borges Leal; Roberta Borges Andrade de Sá; Angélica Leite de Alcântara; João Farias Guerreiro; Ândrea Ribeiro-Dos-Santos; Sidney Emanuel Batista Dos Santos; Paulo Pimentel de Assumpção; Ney Pereira Carneiro Dos Santos

doi:10.3390/genes13030499

Characterization of PCLO Gene in Amazonian Native American Populations

Genes (Basel). 2022 Mar 11;13(3):499. doi: 10.3390/genes13030499.

Authors

Amanda de Nazaré Cohen-Paes^{1

2}, Darlen Cardoso de Carvalho¹, Lucas Favacho Pastana^{1

2}, Elizabeth Ayres Fragoso Dobbin^{1

2}, Fabiano Cordeiro Moreira^{1

2}, Tatiane Piedade de Souza², Marianne Rodrigues Fernandes^{1

2}, Diana Feio da Veiga Borges Leal^{1

2}, Roberta Borges Andrade de Sá^{1

2}, Angélica Leite de Alcântara^{1

2}, João Farias Guerreiro², Ândrea Ribeiro-Dos-Santos^{1

2}, Sidney Emanuel Batista Dos Santos^{1

2}, Paulo Pimentel de Assumpção¹, Ney Pereira Carneiro Dos Santos^{1

2}

Affiliations

¹ Núcleo de Pesquisa em Oncologia, Federal University of Pará, Belém 66073-000, Brazil.
² Laboratório de Genética Humana e Médica, Federal University of Pará, Belém 66073-000, Brazil.

Abstract

Genetic variations in PCLO have been associated with different pathologies in global literature, but there are no data regarding this gene in Native American populations. The Amazonian Native American populations have lower genetic diversity and are more different from other continental groups. We investigated 18 genetic variants in the PCLO gene in Amazonian indigenous and compared our results with the ones found in global populations, which were publicly available in the 1000 Genomes Project, gnmAD and ABraOM databases. The results demonstrated that the variants of the PCLO, especially rs17156844, rs550369696, rs61741659 and rs2877, have a significantly higher frequency in Amerindian populations in comparison with other continental populations. These data outline the singular genetic profile of the Native American population from the Brazilian Amazon region.

Keywords: Brazil; Native American; PCLO; genetic variants; indigenous populations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

American Indian or Alaska Native*
Brazil / epidemiology
Humans