On 'Deuterium exchange of poly-dl-alanine in aqueous solution' by Arieh Berger and K. Linderstrøm-Lang

Andrew P Hinck

doi:10.1016/j.abb.2022.109185

On 'Deuterium exchange of poly-dl-alanine in aqueous solution' by Arieh Berger and K. Linderstrøm-Lang

Arch Biochem Biophys. 2022 Sep 15:726:109185. doi: 10.1016/j.abb.2022.109185. Epub 2022 Mar 20.

Author

Andrew P Hinck¹

Affiliation

¹ Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15208, USA. Electronic address: ahinck@pitt.edu.

PMID: 35321824
DOI: 10.1016/j.abb.2022.109185

Abstract

This commentary highlights the landmark manuscript published in 1957 by Arieh Berger and K. Linderstrøm-Lang that describes the measurement and analysis of hydrogen exchange rates. This highly referenced manuscript is recognized because the impact hydrogen exchange has had on characterizing the structure and dynamics of natively folded proteins and folding intermediates.

Keywords: HDX-MS; Hydrogen exchange; NMR; Protein dynamics; Protein stability.

MeSH terms

Deuterium Exchange Measurement
Deuterium* / chemistry
Hydrogen / chemistry
Peptides* / chemistry
Proteins / chemistry

Substances

Peptides
Proteins
polyalanine
Hydrogen
Deuterium