Placental colonization by Fusobacterium nucleatum is mediated by binding of the Fap2 lectin to placentally displayed Gal-GalNAc

Cell Rep. 2022 Mar 22;38(12):110537. doi: 10.1016/j.celrep.2022.110537.

Abstract

While the existence of an indigenous placental microbiota remains controversial, several pathogens are known to be involved in adverse pregnancy outcomes. Fusobacterium nucleatum is an oral bacterium that is one of several bacteria associated with preterm birth. Oral fusobacteria translocate to the placenta hematogenously; however, the mechanisms localizing them to the placenta remain unclear. Here, using peanut agglutinin, we demonstrate that the level of Gal-GalNAc (Galβ1-3GalNAc; Thomsen Friedenreich antigen) found on trophoblasts facing entering maternal blood rises during gestation and is recognized by the fusobacterial Fap2 Gal-GalNAc lectin. F. nucleatum binding to human and mouse placenta correlates with Gal-GalNAc levels and is reduced upon O-glycanase treatment or with soluble Gal-GalNAc. Fap2-inactivated F. nucleatum shows reduced binding to Gal-GalNAc-displaying placental sections. In a mouse model, intravenously injected Fap2-expressing F. nucleatum, but not a Fap2 mutant, reduces mouse fetal survival by 70%.

Keywords: CP: Developmental biology; CP: Microbiology; Fusobacterium nucleatum; Gal-GalNAc; adverse pregnancy outcomes; placenta.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenomatous Polyposis Coli
  • Animals
  • Antigens, Tumor-Associated, Carbohydrate
  • Female
  • Fusobacterium nucleatum*
  • Lectins
  • Mice
  • Placenta
  • Pregnancy
  • Premature Birth*

Substances

  • Antigens, Tumor-Associated, Carbohydrate
  • Lectins
  • Thomsen-Friedenreich antigen

Supplementary concepts

  • Colorectal Adenomatous Polyposis, Autosomal Recessive