Low-value pharmaceutical care among Dutch GPs: a retrospective cohort study

Br J Gen Pract. 2022 Apr 28;72(718):e369-e377. doi: 10.3399/BJGP.2021.0625. Print 2022 May.

Abstract

Background: Low-value pharmaceutical care exists in general practice. However, the extent among Dutch GPs remains unknown.

Aim: To assess the prevalence of low-value pharmaceutical care among Dutch GPs.

Design and setting: Retrospective cohort study using data from patient records.

Method: The prevalence of three types of pharmaceutical care prescribed by GPs between 2016 and 2019 were examined: topical antibiotics for conjunctivitis, benzodiazepines for non-specific lower back pain, and chronic acid-reducing medication (ARM) prescriptions. Multilevel logistic regression analysis was performed to assess prescribing variation and the influence of patient characteristics on receiving a low-value prescription.

Results: Large variation in prevalence as well as practice variation was observed among the types of low-value pharmaceutical GP care examined. Between 53% and 61% of patients received an inappropriate antibiotics prescription for conjunctivitis, around 3% of patients with lower back pain received an inappropriate benzodiazepine prescription, and 88% received an inappropriate chronic ARM prescription during the years examined. The odds of receiving an inappropriate antibiotic or benzodiazepine prescription increased with age (P<0.001), but decreased for chronic inappropriate ARM prescriptions (P<0.001). Sex affected only the odds of receiving a non-indicated chronic ARM, with males being at higher risk (P<0.001). The odds of receiving an inappropriate ARM increased with increasing neighbourhood socioeconomic status (P<0.05). Increasing practice size decreased the odds of inappropriate antibiotic and benzodiazepine prescriptions (P<0.001).

Conclusion: The results show that the prevalence of low-value pharmaceutical GP care varies among these three clinical problems. Significant variation in inappropriate prescribing exists between different types of pharmaceutical care - and GP practices.

Keywords: general practice; general practitioners; inappropriate prescribing; medical overuse.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Benzodiazepines
  • Conjunctivitis* / drug therapy
  • Drug Prescriptions
  • Humans
  • Inappropriate Prescribing
  • Low Back Pain*
  • Male
  • Pharmaceutical Preparations
  • Practice Patterns, Physicians'
  • Retrospective Studies

Substances

  • Anti-Bacterial Agents
  • Pharmaceutical Preparations
  • Benzodiazepines