Profile of Tissue Immunoglobulin E in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

Jinbo Han; Weiqing Wang; Zhenzhen Zhu; Lei Wang; Yujie Chen; Ruiqi Wang; Kai Guan; Wei Lv

doi:10.1159/000522624

Profile of Tissue Immunoglobulin E in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

Int Arch Allergy Immunol. 2022;183(8):835-842. doi: 10.1159/000522624. Epub 2022 Mar 21.

Authors

Jinbo Han¹, Weiqing Wang², Zhenzhen Zhu², Lei Wang², Yujie Chen², Ruiqi Wang³, Kai Guan³, Wei Lv²

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, adnataster@163.com.
² Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
³ Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Abstract

Introduction: Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) exhibits a poorer prognosis than noneCRSwNP. The aim of this study was to analyze the potential of total immunoglobulin E (tIgE) and specific IgE (sIgE) levels in tissues for distinguishing and assessing eCRSwNP.

Methods: We enrolled 10 control and 88 CRSwNP patients. The clinical data of patients were collected before surgery. Nasal mucosa tissues were taken during surgery for measurements of tIgE, sIgE (weed pollen, epidermal and animal protein, mold, house dust, tree pollen), and subepithelial eosinophil (EOS) counts. The predictive significance of the potential predictors for eCRSwNP was assessed with receiver operating characteristic (ROC) curves.

Results: Nasal polyps tIgE and mold-sIgE were positively correlated with blood and tissue EOSs, comorbid allergic rhinitis and asthma, ethmoid score/total maxillary score ratio, visual analog scale, and CT score. The ROC curve analysis showed that tissue tIgE (p = 0.0004), mold-sIgE (p = 0.0030), blood EOS percentage (p = 0.0003), and absolute blood EOS count (p = 0.0010) acted as predictive factors for eCRSwNP. According to the cutoff value of tissue tIgE of 34.55 ku/L, patients with a high level were more likely to suffer from asthma (p = 0.016) and showed a significantly higher EOS count (p = 0.022), EOS percentage (p = 0.029), and tIgE (p = 0.002) in blood.

Conclusion: Tissue tIgE and mold-sIgE had a significant relationship with the clinical and pathological characteristics of CRSwNP patients and might be reliable for distinguishing and assessing eCRSwNP.

Keywords: Allergic rhinitis; Chronic rhinosinusitis; Eosinophil; Immunoglobulin E; Nasal polyps.

MeSH terms

Animals
Asthma* / pathology
Chronic Disease
Eosinophils / pathology
Immunoglobulin E
Nasal Polyps* / diagnosis
Nasal Polyps* / pathology
Rhinitis* / diagnosis
Rhinitis* / pathology
Sinusitis* / diagnosis
Sinusitis* / pathology

Substances

Immunoglobulin E

Grants and funding

This study was supported by the National Natural Science Foundation of China (82071027); Natural Science Foundation of Beijing (7202162); and Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019XK320034).