Paroxysmal Atrial Fibrillation in Elderly: Worldwide Preliminary Data of LINAC-Based Stereotactic Arrhythmia Radioablation Prospective Phase II Trial

Antonio Di Monaco; Fabiana Gregucci; Ilaria Bonaparte; Federica Troisi; Alessia Surgo; Domenico Di Molfetta; Nicola Vitulano; Federico Quadrini; Roberta Carbonara; Gaetano Martinelli; Pietro Guida; Maria Paola Ciliberti; Alba Fiorentino; Massimo Grimaldi

doi:10.3389/fcvm.2022.832446

Paroxysmal Atrial Fibrillation in Elderly: Worldwide Preliminary Data of LINAC-Based Stereotactic Arrhythmia Radioablation Prospective Phase II Trial

Front Cardiovasc Med. 2022 Mar 2:9:832446. doi: 10.3389/fcvm.2022.832446. eCollection 2022.

Authors

Affiliations

¹ Department of Cardiology, General Regional Hospital F. Miulli, Bari, Italy.
² Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
³ Department of Radiation Oncology, General Regional Hospital F. Miulli, Bari, Italy.
⁴ Department of Radiology, General Regional Hospital F. Miulli, Bari, Italy.

Abstract

Treatment approach for elderly patients with atrial fibrillation (AF) is difficult. The present prospective phase-II trial evaluated LINAC-based stereotactic arrhythmia radioablation safety in this population. The reported data of the first 5 patients worldwide, showed no side effects, absence of AF episodes and without antiarrhythmic drugs.

Trial registration: ClinicalTrials.gov, identifier: NCT04575662.

Keywords: arrhythmia; atrial fibrillation (AF); elderly patients; radioablation; stereotactic body radiotherapy.

Associated data

ClinicalTrials.gov/NCT04575662