Case Report: Detection of Transferrin in a Dog Suspected of Having Cerebrospinal Fluid Rhinorrhea

Kosuke Kinoshita; Hidetaka Nishida; Ryoji Kanegi; Yuya Nakamoto; Toshiyuki Tanaka; Shunsuke Shimamura; Kazuhito Kusumoto; Hideo Akiyoshi

doi:10.3389/fvets.2022.845809

Case Report: Detection of Transferrin in a Dog Suspected of Having Cerebrospinal Fluid Rhinorrhea

Front Vet Sci. 2022 Mar 4:9:845809. doi: 10.3389/fvets.2022.845809. eCollection 2022.

Authors

Kosuke Kinoshita¹, Hidetaka Nishida^{1

2}, Ryoji Kanegi¹, Yuya Nakamoto^{1

3}, Toshiyuki Tanaka¹, Shunsuke Shimamura¹, Kazuhito Kusumoto⁴, Hideo Akiyoshi^{1

2}

Affiliations

¹ Veterinary Medical Center, Osaka Prefecture University, Izumisano, Japan.
² Laboratory of Veterinary Surgery, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Japan.
³ Neuro Vets Animal Neurology Clinic, Kyoto, Japan.
⁴ Wakayama Inter Animal Hospital, Wakayama, Japan.

Abstract

A 12-year-old Yorkshire terrier was referred for epileptic seizures and nasal discharge. The fluid was clear and serous. Cerebrospinal fluid (CSF) rhinorrhea was suspected, based on clinical signs and MRI findings. In humans, analysis of nasal secretions to determine the concentration of glucose and brain-type transferrin has been widely used clinically in order to confirm the presence of CSF rhinorrhea. The glucose concentration in the nasal discharge was 74 mg/dL. Serum-type and brain-type isoforms of transferrin were detectable in the nasal sample. The concentration of glucose and brain-type transferrin could be useful for diagnosing CSF rhinorrhea.

Keywords: CSF leakage; dog; meningitis; rhinorrhea; transferrin.

Publication types

Case Reports