Global Research Status of Multiple Organ Dysfunction Syndrome During 2001-2021: A 20-Year Bibliometric Analysis

Peng-Yue Zhao; Yun Xia; Zheng-Bo Tao; Song-Yan Li; Zhi Mao; Xing-Peng Yang; Ren-Qi Yao; Xiao-Hui Du

doi:10.3389/fmed.2022.814381

Global Research Status of Multiple Organ Dysfunction Syndrome During 2001-2021: A 20-Year Bibliometric Analysis

Front Med (Lausanne). 2022 Mar 4:9:814381. doi: 10.3389/fmed.2022.814381. eCollection 2022.

Authors

Peng-Yue Zhao^{1

2}, Yun Xia³, Zheng-Bo Tao⁴, Song-Yan Li¹, Zhi Mao⁵, Xing-Peng Yang¹, Ren-Qi Yao^{2

6}, Xiao-Hui Du¹

Affiliations

¹ Department of General Surgery, First Medical Center of Chinese PLA General Hospital, Beijing, China.
² Translational Medicine Research Center, Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital, Beijing, China.
³ Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
⁴ Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
⁵ Department of Critical Care Medicine, First Medical Center of Chinese PLA General Hospital, Beijing, China.
⁶ Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, China.

Abstract

Background: Multiple Organ Dysfunction Syndrome (MODS) is a major cause of high morbidity and mortality among patients in intensive care units (ICU). Although numerous basic and clinical researches on MODS have been conducted, there is still a long way to go to prevent patients from entering this stage. To our knowledge, no bibliometric analyses of MODS have been reported, this study, therefore, was conducted to reveal MODS research status and trends during 2001-2021.

Methods: All relevant literature covering MODS during 2001-2021 were extracted from Web of Science. An online analysis platform of literature metrology was used to analyze the publication trends. VOSviewer software was used to collect and analyze the keywords and research hotspots related to MODS.

Results: As of July 31, 2021, a total of 994 MODS-related articles from 2001 to 2021 were identified. The United States accounted for the largest number of publications (31.1%), followed by China and Germany, with 186 and 75 publications, respectively. Among all the institutions, the University of Pittsburgh published the most papers related to MODS (21). Critical Care Medicine published the most papers in this field (106). Professor Moore EE, who had the most citation frequency (1847), made great achievements in MODS research. Moreover, analysis of the keywords identified three MODS research hotspot clusters: "mechanism-related research," "clinical research," and "diagnostic research."

Conclusions: The United States maintained a top position worldwide and made the most outstanding contribution in the MODS field. In terms of publication, China was next only to the United States, but there was a disproportion between the quantity of publications and citation frequency. The institution University of Pittsburgh and journal Critical Care Medicine represent the highest level of research in this field. During the 20 years from 2001 to 2021, basic MODS research has been in-depth yet progressed relatively slowly recently, but the outbreak of COVID-19 has to some extent set off an upsurge of clinical research in MODS field.

Keywords: MODS; bibliometric analysis; keywords; publication; research hotspots.