Glutathione-Responsive Heterogeneous Metal-Organic Framework Hybrids for Photodynamic-Gene Synergetic Cell Apoptosis

Chemistry. 2022 Jun 1;28(31):e202200305. doi: 10.1002/chem.202200305. Epub 2022 Apr 21.

Abstract

A core-shell heterogeneous metal-organic framework (MOF) hybrid is sequentially designed by a photosensitized porous coordination network (PCN)-typed MOF as core and Cu2+ -centered zeolitic imidazolate framework (ZIF-67) as shell encapsulating cyanine 3-labelled siRNA. The heterogeneous MOF hybrid realized stimulus-responsive photodynamic therapy (PDT) and controllable siRNA delivery through 1 O2 -assistant endosomal escape for imaging-guided photodynamic-gene synergetic theranostics.

Keywords: biosensors; glutathione; heterogeneous structures; metal-organic frameworks; singlet oxygen.

MeSH terms

  • Apoptosis
  • Glutathione
  • Metal-Organic Frameworks*
  • Photochemotherapy*
  • Photosensitizing Agents
  • RNA, Small Interfering

Substances

  • Metal-Organic Frameworks
  • Photosensitizing Agents
  • RNA, Small Interfering
  • Glutathione