An overview of poly (amide-amine) dendrimers functionalized chromatographic separation materials

Dandan Guo; Xiaoqian Zhou; Nadeem Muhammad; Shaohua Huang; Yan Zhu

doi:10.1016/j.chroma.2022.462960

An overview of poly (amide-amine) dendrimers functionalized chromatographic separation materials

J Chromatogr A. 2022 Apr 26:1669:462960. doi: 10.1016/j.chroma.2022.462960. Epub 2022 Mar 11.

Authors

Dandan Guo¹, Xiaoqian Zhou², Nadeem Muhammad³, Shaohua Huang⁴, Yan Zhu⁵

Affiliations

¹ Institute of Drug Discovery and Technology, Ningbo University, Ningbo 315211, China; Qian Xuesen Collaborative Research Center for Astrochemistry and Space Life Sciences, Ningbo University, Ningbo 315211, China; Department of Chemistry, Zhejiang University, Hangzhou 310028, China.
² Institute of Drug Discovery and Technology, Ningbo University, Ningbo 315211, China.
³ Department of Chemistry, Zhejiang University, Hangzhou 310028, China; Department of Environmental Engineering, Wuchang University of Technology, Wuhan 430223, China.
⁴ Institute of Drug Discovery and Technology, Ningbo University, Ningbo 315211, China; Qian Xuesen Collaborative Research Center for Astrochemistry and Space Life Sciences, Ningbo University, Ningbo 315211, China. Electronic address: huangshaohua@nbu.edu.cn.
⁵ Department of Chemistry, Zhejiang University, Hangzhou 310028, China. Electronic address: zhuyan@zju.edu.cn.

PMID: 35305456
DOI: 10.1016/j.chroma.2022.462960

Abstract

Chromatography is one of the most important separation techniques in analytical chemistry. In which, the separation materials are the core for good separation results. Poly (amide-amine) dendrimers with regular three-dimensional structure, abundant terminal groups, controllable molecule chains, and unique cavities appear to have a positive impact on chromatographic separation materials. In the past decades, poly (amide-amine) grafted adsorbents and stationary phases have presented high grafting efficiency, controllable surface structure, good dispersion, and wide practical applications. In this review, the prepared poly (amide-amine) functionalized separation materials and their applications are systematically summarized. Functions, significance, structure-actvity relationships and benefits of poly (amide-amine) dendrimers in the proposed separation materials are discussed in detail. And we hope to provide a useful reference for the future development of chromatographic separation materials and inspire new discoveries in the study of poly (amide-amine) functionalized materials.

Keywords: Adsorbent; Chromatography; PAMAM dendrimers; Stationary phase.

Publication types

Review

MeSH terms

Amides / chemistry
Amines*
Chromatography
Dendrimers* / chemistry

Substances

Amides
Amines
Dendrimers