Cocktail party: Low-dose antibody combinations deliver pan-ebolavirus protection

Scott M Anthony; Lisa E Hensley

doi:10.1016/j.cell.2022.01.025

Cocktail party: Low-dose antibody combinations deliver pan-ebolavirus protection

Cell. 2022 Mar 17;185(6):943-945. doi: 10.1016/j.cell.2022.01.025.

Authors

Scott M Anthony¹, Lisa E Hensley²

Affiliations

¹ Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA. Electronic address: scott.anthony@nih.gov.
² Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA. Electronic address: lisa.hensley@nih.gov.

PMID: 35303426
DOI: 10.1016/j.cell.2022.01.025

Abstract

Recent outbreaks of Ebola have brought to the forefront the need for focused therapeutic treatments. In this issue of Cell, Milligan and colleagues build on previous studies of antibody treatments for Ebola virus disease, uncovering broad synergistic protective immunity when administered in combination (as antibody cocktails).

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Antibodies, Monoclonal / immunology
Antibodies, Neutralizing / immunology
Antibodies, Neutralizing / therapeutic use
Antibodies, Viral / immunology
Antibodies, Viral / therapeutic use
Ebolavirus* / immunology
Epitopes / immunology
Hemorrhagic Fever, Ebola* / drug therapy
Hemorrhagic Fever, Ebola* / immunology
Hemorrhagic Fever, Ebola* / prevention & control
Humans

Substances

Antibodies, Monoclonal
Antibodies, Neutralizing
Antibodies, Viral
Epitopes

Grants and funding

HHSN272201800013C/AI/NIAID NIH HHS/United States