α-tocopherol pretreatment alleviates cerebral ischemia-reperfusion injury in rats

CNS Neurosci Ther. 2022 Jun;28(6):964-970. doi: 10.1111/cns.13814. Epub 2022 Mar 18.

Abstract

α-tocopherol showed antioxidant, anti-inflammatory and anti-apoptotic abilities in rat brain tissue, thus alleviating cerebral ischemia-reperfusion injury-induced nerve damage.

Keywords: apoptosis; cerebral; inflammation; ischemia-reperfusion injury; oxidative stress; α-tocopherol.

Publication types

  • Letter

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Apoptosis
  • Brain Ischemia* / drug therapy
  • Oxidative Stress
  • Rats
  • Reperfusion Injury* / drug therapy
  • alpha-Tocopherol / pharmacology
  • alpha-Tocopherol / therapeutic use

Substances

  • Antioxidants
  • alpha-Tocopherol