BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies

Xiaoyu Fu; Wei Tan; Qibin Song; Huadong Pei; Juanjuan Li

doi:10.3389/fcell.2022.813457

BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies

Front Cell Dev Biol. 2022 Mar 1:10:813457. doi: 10.3389/fcell.2022.813457. eCollection 2022.

Authors

Xiaoyu Fu^{1

2}, Wei Tan³, Qibin Song², Huadong Pei⁴, Juanjuan Li^{1

2}

Affiliations

¹ Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
² Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.
³ Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
⁴ Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States.

Abstract

Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiological processes. Mutations or defects in the BRCA1 gene significantly increase the risk of breast, ovarian, prostate, and other cancers in carriers. In this review, we summarized the molecular functions and regulation of BRCA1 and discussed recent insights into the detection and treatment of BRCA1 mutated breast cancer.

Keywords: BRCA1; breast cancer; detection; gene mutation; personalized and precision medicine (PPM).

Publication types

Review