Inflammatory Microenvironment of Skin Wounds

Zhen Wang; Fang Qi; Han Luo; Guangchao Xu; Dali Wang

doi:10.3389/fimmu.2022.789274

Inflammatory Microenvironment of Skin Wounds

Front Immunol. 2022 Mar 1:13:789274. doi: 10.3389/fimmu.2022.789274. eCollection 2022.

Authors

Zhen Wang^{1

2}, Fang Qi^{1

2}, Han Luo^{1

2}, Guangchao Xu^{1

2}, Dali Wang^{1

2}

Affiliations

¹ Department of Plastic Surgery and Burns, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
² The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, China.

Abstract

Wound healing is a dynamic and highly regulated process that can be separated into three overlapping and interdependent phases: inflammation, proliferation, and remodelling. This review focuses on the inflammation stage, as it is the key stage of wound healing and plays a vital role in the local immune response and determines the progression of wound healing. Inflammatory cells, the main effector cells of the inflammatory response, have been widely studied, but little attention has been paid to the immunomodulatory effects of wound healing in non-inflammatory cells and the extracellular matrix. In this review, we attempt to deepen our understanding of the wound-healing microenvironment in the inflammatory stage by focusing on the interactions between cells and the extracellular matrix, as well as their role in regulating the immune response during the inflammatory stage. We hope our findings will provide new ideas for promoting tissue regeneration through immune regulation.

Keywords: extracellular matrix; inflammatory cells; inflammatory microenvironment; non-inflammatory cells; wound healing.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Extracellular Matrix
Humans
Immunomodulation
Inflammation
Soft Tissue Injuries*
Wound Healing* / physiology